PMID- 28415774
OWN - NLM
STAT- Publisher
DA  - 20170418
LR  - 20170418
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
DP  - 2017 Mar 15
TI  - Chemoprevention of prostate cancer in men with high-grade prostatic
      intraepithelial neoplasia (HGPIN): a systematic review and adjusted indirect
      treatment comparison.
LID - 10.18632/oncotarget.16230 [doi]
AB  - BACKGROUND: High-grade prostatic intraepithelial neoplasia (HGPIN) is the
      precursor or premalignant form of prostate cancer. At least 30% patients with a
      confirmed HGPIN will develop prostate cancer within 1 year after repeated biopsy.
      HGPIN patients are the appropriate at-risk population for chemoprevention
      strategies investigation against prostate cancer. However the commonly used
      chemoprevention agents that targeted on hormonal imbalance or lifestyle-related
      factors showed varied results in HGPIN patients. METHOD: Literature searches were
      conducted in PubMed, EMBASE and Cochrane library according to Cochrane guidelines
      before January 31st, 2017. Direct meta-analysis were performed to summarize the
      efficacy of candidate chemopreventative agents Dutasteride, Flutamide,
      Toremifene, Selenium, Green tea components, Lycopene and natural food products
      combination. Adjusted indirect meta-analyses were employed to compare the
      relative efficacy of these candidate chemoprevention agents head-to-head.
      RESULTS: The overall incidence of prostate cancer in HGPIN was slightly decreased
      by chemoprevention agents (25.7% vs 31.5%, RR = 0.92, 95% CI: 0.83-1.03, P =
      0.183), with minor heterogeneity (I2 = 22.3%, X2 = 15.08, P = 0.237), but without
      statistical significance. Subgroup analysis showed that green tea catechins
      significantly decreased prostate cancer in HGPIN patients (7.60% vs 23.1%, RR =
      0.39, 95% CI: 0.16-10.97, P P = 0.044), with moderate heterogeneity (I2 = 47.9%, 
      X2 = 1.92, P = 0.166). The adjusted indirect meta-analysis favored green tea
      catechins over other chemoprevention agents, and significantly when compared to
      natural food products combination (RR = 0.355, 95% CI: 0.134-0.934). CONCLUSION: 
      The overall efficacy of chemoprevention agents in HGPIN patients is limited. But 
      Green tea catechins showed the superiority to decrease prostate cancer in HGPIN
      patients.
FAU - Cui, Kang
AU  - Cui K
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
FAU - Li, Xiangnan
AU  - Li X
AD  - Department of Thoracic Surgery, The First Affiliation Hospital of Zhengzhou
      University, Zhengzhou, Henan, China.
FAU - Du, Yabing
AU  - Du Y
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
FAU - Tang, Xiance
AU  - Tang X
AD  - Department of Medical Affairs, Henan Cancer Hospital, Affiliated Cancer Hospital 
      of Zhengzhou University, Zhengzhou, Henan, China.
FAU - Arai, Seiji
AU  - Arai S
AD  - Department of Hematology and Oncology, Beth Israel Deaconess Medical Center,
      Harvard Medical School, Boston, Massachusetts, United States.
AD  - Department of Urology, Gunma University Graduate School of Medicine, Maebashi,
      Japan.
FAU - Geng, Yiwei
AU  - Geng Y
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
FAU - Xi, Ying
AU  - Xi Y
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
FAU - Xu, Han
AU  - Xu H
AD  - Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou
      University, Zhengzhou, Henan, China.
FAU - Zhou, Yue
AU  - Zhou Y
AD  - Deparmtent of B-Ultrasound, The First Affiliated Hospital of Zhengzhou
      University, Zhengzhou, Henan, China.
FAU - Ma, Wang
AU  - Ma W
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
FAU - Zhang, Tengfei
AU  - Zhang T
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University,
      Zhengzhou, Henan, China.
LA  - eng
PT  - Meta-Analysis
DEP - 20170315
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
OTO - NOTNLM
OT  - HGPIN
OT  - adjusted indirect meta-analysis
OT  - chemoprevention
OT  - green tea catechins
OT  - prostate cancer
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2017/02/12 [received]
PHST- 2017/03/06 [accepted]
AID - 16230 [pii]
AID - 10.18632/oncotarget.16230 [doi]
PST - aheadofprint
SO  - Oncotarget. 2017 Mar 15. doi: 10.18632/oncotarget.16230.